Police seized around £170,000-worth of drugs from a car in Douglas this morning.
Officers say two women from Liverpool, aged 24 and 27, were detained at a hotel in Douglas at around 6.30am and their vehicle searched.
Approximately £108,000-worth of cannabis resin, and £62,000-worth of what's thought to be cocaine, was found.
The women are currently at police headquarters, helping officers with their inquiries.