Vagas ladies tackle Ashfield at home
Ramsey start the play-off stage of the season in the Lancashire/Cheshire One Shield away at New Brighton.
The northerners have a weakened squad travelling due injury and unavailability.
They made the trip to New Brighton earlier in the campaign and suffered a heavy 59-0 defeat.
Vagabonds ladies entertain Ashfield in Women's NC1 North West at Ballafletcher looking for a strong finish to the season and possibly a top three position.
They did win 34-15 in the away game in Nottinghamshire.
There are two fixtures in the Manx Shield where Douglas Celts have already secured the title.
Emerging Nomads play Vagabonds Hornets at KWC and Ramsey "B" welcome Western Vikings to the Mooragh Park.